It is likely, being an invention utilized by the Illuminati and Majestic 12, that it was researched and developed by using unwilling human test subjects. It was created as a quick method of augmentation en masse, for having augmented agents with absolute loyalty and without the robotic non-standard appearance of mechanical augmentation or the unpredictability of nanotechnological augmentation. The physiopharmaceutical augmentation was probably created between the widespread use of mechanical augmentation and the experimentation on nanotechnological augmentation, before the creation of the Majestic 12, between 20. 3 List of physiopharmaceutically augmented.2 List of physiopharmaceutical augmentations.